Intestinal Yeast or Clostridial Overgrowth

Microbiome – Trillions of beneficial bacteria

Yeast is normal resident

• Can overgrow when insufficient beneficial bacteria (due to antibiotic use or inadequate fiber intake)

Yeast secrete toxins.

• They can affect intestinal lining and also leak across into bloodstream.

• Some mimic Krep’s cycle metabolites.

Toxins can affect brain function.

Common symptoms

Brain fog

can arise from the brain being highly used for a long time which will affect loss in concentration, slow thinking, or easy to forget. Additionally, it will affect mental fatigue and mood changes.

Inattention

Unexplained laughing

Sugar cravings

Yeast can also trigger intestinal inflammation

Can measure yeast and Clostridia toxins in Urine organic acid

Can also do GI Effect stool testing – cell culture, KOH preparation for yeast, Polymerase Chain Reaction (PCR)

Treatments

• Biotin, probiotics, anti-fungal medications/herbs

Clostridia Overgrowth

• Clostridia bacteria also secrete toxins which is 4-cresol from Clostridium difficile

• These can affect brain function

• Also may secrete propionic acid (PPA) in urine

• Dr. Derrick McFabe’s study – injected PPA into rat brains -> immediately looked autistic

Treatments

• Probiotics, Saccharomyces boulardii (“beneficial yeast”), Vancomycin

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